If you open an IndexedDB connection in an iframe, it throws a SecurityError, that is completely normal if you are in a cross-origin context. But what if you are in a domain, say "a.example.com", and you embed an iframe with "src" equal to "b.a.example.com". The standard (https://html.spec.whatwg.org/multipage/origin.html#relaxing-the-same-origin-restriction) states that you can relax the same-origin restriction that would usually by applied by setting the "document.domain" to the same Second-Level Domain (SLD) in both parent and child contexts. In my example, setting "document.domain" to "example.com" in the top window and the iframe window is legit and should put both in a same-origin context. Here is a reproduction link (http://a.indigital.io) with a minimalist context. The iframe loads http://b.a.indigital.io, which is a subdomain of the opening window.